Macrophage activation syndrome (MAS) in juvenile systemic lupus erythematosus (JSLE): an underrecognized complication?
نویسندگان
چکیده
Open Access Poster presentation Macrophage activation syndrome (MAS) in juvenile systemic lupus erythematosus (JSLE): an underrecognized complication? A Parodi*1, S Davì1, AB Pringe2, S Magni-Manzoni3, P Miettunen4, B BaderMeunier5, G Espada6, S Ozen7, D Wright8, C Magalhaes9, P Woo10, R Kubchandani11, A Grom12, H Michels13, C Wouters14, CE Toro Gutierrez16, G Sterba15, K Hayward17, D Guseinova18, A Fischer19, E Cortis20, M Vivarelli20, A Pistorio1, N Ruperto1, I Sala1, A Martini21 and A Ravelli21
منابع مشابه
Macrophage Activation Syndrome: A Report of Two Cases and a Literature Review
Macrophage activation syndrome (MAS) is a severe, potentially fatal condition that may complicate autoimmune diseases, and it belongs to hemophagocytic lymphohistiocytosis (HLH) disorders. MAS occurs in adults and children. However, it is rare in juvenile systemic lupus erythematosus (jSLE), and it is extremely rare to be the initial presentation of jSLE. Here, we report two patients with juven...
متن کاملMacrophage activation syndrome: an under-recognised complication in juvenile systemic lupus erythematosus
Macrophage activation syndrome (MAS) is a life-threatening complication in juvenile systemic lupus erythematosus(J SLE). We report three cases of MAS in Juvenile SLE which occurred over the last 6 months. Interestingly, in all the 3 cases, MAS occurred acutely at the time of first presentation of lupus. All of them had fever at presentation. Two of them had lymphadenopathy and splenomegaly and ...
متن کاملAssociation of Macrophage Activating Syndrome with Castleman’s Syndrome in Systemic Lupus Erythematosus
Macrophage Activating Syndrome (MAS) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, Still's disease, polyarteritis nodosa. It is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. A 27 yr. old female patient was admitted in shahid Mostafa Khomeini Hospital (Tehran-Ira...
متن کاملSuccessful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels
BACKGROUND Macrophage activation syndrome (MAS) is the secondary hemophagocytic lymphohistiocytosis associated with rheumatic diseases. Recently, the different cytokine profiles between systemic juvenile idiopathic arthritis (sJIA)-associated MAS (sJIA-MAS) and juvenile systemic lupus erythematosus (JSLE)-associated MAS (JSLE-MAS) were reported. However, there is little information about juveni...
متن کاملMethotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS s...
متن کامل